No evidence for zoonotic transmission of H3N8 canine influenza virus among US adults occupationally exposed to dogs
Article first published online: 15 NOV 2013
© 2013 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
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Influenza and Other Respiratory Viruses
Volume 8, Issue 1, pages 99–106, January 2014
How to Cite
2014) No evidence for zoonotic transmission of H3N8 canine influenza virus among US adults occupationally exposed to dogs. Influenza and Other Respiratory Viruses 8(1), 99–106.et al. (
- Issue published online: 20 DEC 2013
- Article first published online: 15 NOV 2013
- Manuscript Accepted: 26 SEP 2013
- University of Florida Emerging Pathogens Institute
- US Department of Defense Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance
- National Institute of Allergy and Infectious Diseases. Grant Number: R01 AI068803
- Communicable diseases;
- Dog diseases;
- influenza A virus;
- occupational exposure;
- seroepidemiologic studies;
The zoonotic potential of H3N8 canine influenza virus (CIV) has not been previously examined; yet considering the popularity of dogs as a companion animal and the zoonotic capabilities of other influenza viruses, the public health implications are great. This study aimed to determine the seroprevalence of antibodies against CIV among a US cohort.
A cross-sectional seroepidemiological study was conducted between 2007 and 2010.
Recruitments primarily occurred in Iowa and Florida. Participants were enrolled at dog shows, or at their home or place of employment.
Three hundred and four adults occupationally exposed to dogs and 101 non-canine-exposed participants completed a questionnaire and provided a blood sample.
Main outcome measures
Microneutralization and neuraminidase inhibition assays were performed to detect human sera antibodies against A/Canine/Iowa/13628/2005(H3N8). An enzyme-linked lectin assay (ELLA) was adapted to detect antibodies against a recombinant N8 neuraminidase protein from A/Equine/Pennsylvania/1/2007(H3N8).
For all assays, no significant difference in detectable antibodies was observed when comparing the canine-exposed subjects to the non-canine-exposed subjects.
While these results do not provide evidence for cross-species CIV transmission, influenza is predictably unpredictable. People frequently exposed to ill dogs should continually be monitored for novel zoonotic CIV infections.