Heat inactivation of the Middle East respiratory syndrome coronavirus
Version of Record online: 29 JUL 2014
© 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
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Influenza and Other Respiratory Viruses
Volume 8, Issue 5, pages 585–586, September 2014
How to Cite
2014) Heat inactivation of the Middle East respiratory syndrome coronavirus. Influenza and Other Respiratory Viruses 8(5), 585–586.et al. (
- Issue online: 10 SEP 2014
- Version of Record online: 29 JUL 2014
- Manuscript Accepted: 8 MAY 2014
- European Union's Seventh Framework Programme. Grant Number: 278433-PREDEMICS
The culture supernatants of the emerging Middle East respiratory syndrome coronavirus (MERS-CoV) were submitted to three temperatures over time and tested for infectivity by TCID50 method on Vero E6 cells. At 56°C, almost 25 minutes were necessary to reduce the initial titre by 4 log10. Increasing temperature to 65°C had a strong negative effect on viral infectivity as virucidy dropped significantly to 1 minute. On the contrary, no significant decrease in titre was observed after 2 hours at 25°C. These data might be useful in establishing biosafety measures in laboratories against MERS-CoV.