Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study
Version of Record online: 16 JAN 2004
Acta Psychiatrica Scandinavica
Volume 109, Issue 2, pages 140–146, February 2004
How to Cite
Serra-Mestres, J., Ring, H. A., Costa, D. C., Gacinovic, S., Walker, Z., Lees, A. J., Robertson, M. M. and Trimble, M. R. (2004), Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study. Acta Psychiatrica Scandinavica, 109: 140–146. doi: 10.1111/j.0001-690X.2004.00214.x
- Issue online: 16 JAN 2004
- Version of Record online: 16 JAN 2004
- Accepted for publication June 11, 2003
- dopamine transporters;
- Tourette's disorder;
Objective: To investigate dopamine transporter binding in Gilles de la Tourette syndrome (GTS) with SPECT and [123I]FP-CIT.
Method: Ten neuroleptic naïve/free patients with GTS, and 10 age- and gender-matched normal volunteers were studied. Subjects were clinically evaluated. GTS severity and affective symptoms were measured and the presence of GTS-related behaviours were recorded.
Results: The GTS group showed significantly higher binding in both caudate and putamen nuclei than the controls. No associations were found between striatal binding ratios and measures of affect or GTS-related behaviours.
Conclusion: Patients with GTS show higher striatal binding of FP-CIT to the striatum in comparison with age- and gender-matched control subjects, indicating that dopamine transporter abnormalities are involved in the pathophysiology of GTS. These abnormalities appear to be distributed across both caudate and putamen.