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High-grade vulval intraepithelial neoplasia (VIN 3): a retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989–1999

Authors

  • Peter Sykes,

    Corresponding author
    1. Departments of Obstetrics and Gynaecology and of Surgery, Christchurch School of Medicine, Christchurch, New Zealand
      Address for correspondence
      Peter Sykes
      Department of Obstetrics and Gynaecology
      Christchurch School of Medicine
      Christchurch
      New Zealand
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  • Natasha Smith,

    1. Departments of Obstetrics and Gynaecology and of Surgery, Christchurch School of Medicine, Christchurch, New Zealand
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  • Peter McCormick,

    1. Departments of Obstetrics and Gynaecology and of Surgery, Christchurch School of Medicine, Christchurch, New Zealand
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  • Frank A Frizelle

    1. Departments of Obstetrics and Gynaecology and of Surgery, Christchurch School of Medicine, Christchurch, New Zealand
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  • Peter Sykes Senior Lecturer and Gynaecological Oncologist, Natasha Smith Medical Student, Peter McCormick Consultant Obstetrician and Gynaecologist, Frank A Frizelle Colorectal Surgeon

Address for correspondence
Peter Sykes
Department of Obstetrics and Gynaecology
Christchurch School of Medicine
Christchurch
New Zealand

Abstract

ABSTRACT

Objectives

To determine patient and disease characteristics, treatment patterns and long-term outcomes, in order to help direct management of patients with VIN 3, to examine the risk of development of cancer following a diagnosis of VIN 3 and the risk of recurrent disease requiring multiple treatment episodes, and to review patients with vulval cancer, in order to establish the relative prevalence of VIN 3 related vulval cancers.

Design

Retrospective chart review of 65 consecutive patients diagnosed with VIN 3 between 1989 and 1999.

Population or sample

All patients diagnosed with VIN 3 at Christchurch Womens' Hospital (1 January 1989 to 31 December 1999) and Dunedin Public Hospital (1 January 1990 to 31 December 1999)

Main outcome measures

Age at diagnosis, symptoms, medical history, disease characteristics, treatment, outcome and follow-up.

Results

The median age at diagnosis was 38 years. Smokers were younger than non-smokers. Two-thirds had associated dysplasia of the lower genital tract, 43% had high-grade lesions. Seventy-nine per cent were symptomatic for a median of 9.5 months. All had macroscopically visible disease. Colposcopy and histology diagnoses correlated in 72% of cases. Treatment by local excision was undertaken in 84% of cases of which 65% had involved margins. Fifty-one per cent required further treatment, risk factors were positive margins and multifocal disease. Three developed micro-invasive cancer.

Conclusions

Treatment by local excision is both diagnostic and therapeutic. Excision may reveal micro-invasive cancer, patients are usually symptomatic and VIN 3 has some potential to become invasive. Treated patients may develop microinvasive disease but frank invasion was not seen. The true rate of malignant progression in untreated patients remains unclear and radical surgery is rarely indicated. All patients require long-term follow up.

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