Nonparametric Identification of the Minimum Effective Dose
Article first published online: 25 MAY 2004
Volume 55, Issue 4, pages 1236–1240, December 1999
How to Cite
Chen, Y.-I. (1999), Nonparametric Identification of the Minimum Effective Dose. Biometrics, 55: 1236–1240. doi: 10.1111/j.0006-341X.1999.01236.x
- Issue published online: 25 MAY 2004
- Article first published online: 25 MAY 2004
- Received March 1998. Revised August 1998 and January 1999. Accepted January 1999.
- Dose–response study;
- Monte Carlo study;
- One-way layout;
- Step-down closed test
Summary. We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is denned to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann–Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonparametric procedure. Finally, the comparative results of a Monte Carlo level and power study for small sample sizes are presented and discussed.