Rank-Based Tests for Dose Finding in Nonmonotonic Dose–Response Settings
Article first published online: 25 MAY 2004
Volume 55, Issue 4, pages 1258–1262, December 1999
How to Cite
Chen, Y.-I. (1999), Rank-Based Tests for Dose Finding in Nonmonotonic Dose–Response Settings. Biometrics, 55: 1258–1262. doi: 10.1111/j.0006-341X.1999.01258.x
- Issue published online: 25 MAY 2004
- Article first published online: 25 MAY 2004
- Received November 1998. Revised February 1999. Accepted March 1999.
- Dose–response study;
- Lim–Wolfe test;
- Monte Carlo study;
- Randomized block design;
- Step-down closed test;
- Umbrella-pattern treatment effects
Summary. Lim and Wolfe (1997, Biometrics53, 410–418) proposed rank-based multiple test procedures for identifying the dose levels that are more effective than the zero-dose control in randomized complete block designs when it can be assumed that the efficacy of the increasing dose levels is monotonically increasing up to a point, followed by a monotonic decrease. Modifications of the Lim–Wolfe tests are suggested that provide more practical and powerful alternatives. Two numerical examples are illustrated and the results of a Monte Carlo power study are presented.