Current address: School of Public Health, Saint Louis University, Saint Louis, Missouri 63108-3342, U.S.A.
The Variance for the Disequilibrium Coefficient in the Individual Hardy–Weinberg Test
Article first published online: 25 MAY 2004
Volume 55, Issue 4, pages 1269–1272, December 1999
How to Cite
Chen, J. J. and Thomson, G. (1999), The Variance for the Disequilibrium Coefficient in the Individual Hardy–Weinberg Test. Biometrics, 55: 1269–1272. doi: 10.1111/j.0006-341X.1999.01269.x
- Issue published online: 25 MAY 2004
- Article first published online: 25 MAY 2004
- Received July 1998. Revised November 1998. Accepted January 1999.
- Disequilibrium coefficient;
- Hardy–Weinberg test;
- Individual test
Summary. It is of interest to detect the deviation from Hardy–Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics45, 53–70) suggested a disequilibrium coefficient approach and proposed a 1-d.f.2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.