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Keywords:

  • Disequilibrium coefficient;
  • Hardy–Weinberg test;
  • Individual test

Summary. It is of interest to detect the deviation from Hardy–Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics45, 53–70) suggested a disequilibrium coefficient approach and proposed a 1-d.f.2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.