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Keywords:

  • Block design;
  • Composite sampling;
  • Experimental design;
  • Gene expression;
  • Microarray;
  • Replication

Summary This article describes the theoretical and practical issues in experimental design for gene expression microarrays. Specifically, this article 1) discusses the basic principles of design (randomization, replication, and blocking) as they pertain to microarrays, and 2) provides some general guidelines for statisticians designing microarray studies.