Exact Analysis of Dose Response for Multiple Correlated Binary Outcomes
Article first published online: 11 MAR 2004
Volume 60, Issue 1, pages 216–224, March 2004
How to Cite
Han, K. E., Catalano, P. J., Senchaudhuri, P. and Mehta, C. (2004), Exact Analysis of Dose Response for Multiple Correlated Binary Outcomes. Biometrics, 60: 216–224. doi: 10.1111/j.0006-341X.2004.00152.x
- Issue published online: 11 MAR 2004
- Article first published online: 11 MAR 2004
- Received October 2002. Revised June 2003. Accepted August 2003.
- Binary data;
- Exact test;
- Multiple outcomes;
- Network algorithm
Summary. The neurotoxicity of a substance is often tested using animal bioassays. In the functional observational battery, animals are exposed to a test agent and multiple outcomes are recorded to assess toxicity, using approximately 40 animals measured on up to 30 different items. This design gives rise to a challenging statistical problem: a large number of outcomes for a small sample of subjects. We propose an exact test for multiple binary outcomes, under the assumption that the correlation among these items is equal. This test is based upon an exponential model described by Molenberghs and Ryan (1999, Environmetrics10, 279–300) and extends the methods developed by Corcoran et al. (2001, Biometrics57, 941–948) who developed an exact test for exchangeably correlated binary data for groups (clusters) of correlated observations. We present a method that computes an exact p-value testing for a joint dose–response relationship. An estimate of the parameter for dose response is also determined along with its 95% confidence bound. The method is illustrated using data from a neurotoxicity bioassay for the chemical perchlorethylene.