Candidate genes for recessive non-syndromic mental retardation on chromosome 3p (MRT2A)*


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    This research was funded by a grant from NINDS to Dr Higgins (R01 NS42422).

Dr Joseph J. Higgins, Director, Center for Human Genetics and Child Neurology, Mid-Hudson Family Health Institute, 279 Main Street, Suite 203A, New Paltz, NY 12561, USA.
Tel.: 845 256 1155
fax.: 845 256 1375


A mild type of autosomal recessive, non-syndromic mental retardation (NSMR) is linked to loci on chromosome 3p. This report delimits the MRT2A minimal critical region to 4.2 Mb between loci D3S3630 and D3S1304. This interval contains nine genes (IL5RA, TRNT1, LRRN1, SETMAR, SUMF1, ITPR1, BHLHB2, EDEM, and MRPS36P1). The results suggest that a mutation does not exist in these genes and that an unknown transcript in the region contributes to the cognitive deficits in NSMR.