Present address: Department of Zoology, Oregon State U Corvallis, Oregon 97331; E-mail: firstname.lastname@example.org
RAPID FITNESS RECOVERY IN MUTATIONALLY DEGRADED LINES OF CAENORHABDITIS ELEGANS
Article first published online: 9 MAY 2007
Volume 57, Issue 5, pages 1022–1030, May 2003
How to Cite
Estes, S. and Lynch, M. (2003), RAPID FITNESS RECOVERY IN MUTATIONALLY DEGRADED LINES OF CAENORHABDITIS ELEGANS. Evolution, 57: 1022–1030. doi: 10.1111/j.0014-3820.2003.tb00313.x
- Issue published online: 9 MAY 2007
- Article first published online: 9 MAY 2007
- Received March 29, 2002. Accepted December 12, 2002.
- Caenorhabditis elegans;
- compensatory mutation;
- life-history characters;
- mutation accumulation;
- mutation load;
- natural selection
Abstract Deleterious mutation accumulation has been implicated in many biological phenomena and as a potentially significant threat to human health and the persistence of small populations. The vast majority of mutations with effects on fitness are known to be deleterious in a given environment, and their accumulation results in mean population fitness decline. However, whether populations are capable of recovering from negative effects of prolonged genetic bottlenecks via beneficial or compensatory mutation accumulation has not previously been tested. To address this question, long-term mutation-accumulation lines of the nematode Caenorhabditis elegans, previously propagated as single individuals each generation, were maintained in large population sizes under competitive conditions. Fitness assays of these lines and comparison to parallel mutation-accumulation lines and the ancestral control show that, while the process of fitness restoration was incomplete for some lines, full recovery of mean fitness was achieved in fewer than 80 generations. Several lines of evidence indicate that this fitness restoration was at least partially driven by compensatory mutation accumulation rather than a result of a generic form of laboratory adaptation. This surprising result has broad implications for the influence of the mutational process on many issues in evolutionary and conservation biology.