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Keywords:

  • anti-anxiety agents;
  • venlafaxine XR;
  • generalized anxiety disorder;
  • anxiety disorders;
  • comorbidity

Objective: To present the results of numerous studies that assessed the efficacy, safety and tolerability of venlafaxine extended release (XR) in treating anxiety disorders, particularly generalized anxiety disorder (GAD).

Method: Efficacy was assessed with the Hamilton Rating Scale for Anxiety, Clinical Global Impressions scale, Hospital Anxiety and Depression scale and other instruments. Standard safety and tolerability assessments were used.

Results: In four placebo-controlled trials, venlafaxine XR was effective and well tolerated in patients with GAD. Several additional smaller studies found venlafaxine XR effective in treating anxiety associated with social phobia, obsessive-compulsive disorder and panic disorder.

Conclusion: Venlafaxine XR has both short- and long-term efficacy and tolerability in treating symptoms of long-term anxiety and comorbid anxiety and depression, and in achieving remission in GAD patients. These characteristics, combined with early onset of anxiolytic action and dose–response effect, make it a logical choice for treating anxiety occurring alone or comorbidly with depression.