A patch test study of 27 crude drugs commonly used in Chinese topical medicaments

Authors

  • Hsuan-Hsiang Chen,

    1. Departments of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • Chee-Ching Sun,

    Corresponding author
    1. Departments of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • Mei-Ping Tseng,

    1. Departments of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • Chih-Jung Hsu

    1. Departments of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Chee-Ching Sun, MD
Department of Dermatology
National Taiwan University Hospital
7, Chung-Shan South Road
Taipei, Taiwan
Tel: + 886 2 2356 2141
Fax: + 886 2 2393 4177
e-mail: chee@ha.mc.ntu.edu.tw

Abstract

Chinese topical medicaments (CTMs) are commonly used in Taiwan and in Southeast Asia. However, a systematic evaluation of contact sensitization potential from CTM has not been carried out to our knowledge. This study was undertaken to investigate the incidence of contact sensitivity to the components of CTM in patients with contact dermatitis from CTM. A screening series of 27 crude drugs most commonly used in CTM as well as a modified European standard series was patch tested in 30 patients. The herbs with the most frequent positive reactions were Flos Caryophylli ( inline image), Radix Angelicae Pubescentis ( inline image), Cortex Cinnamomi ( inline image), Cortex Radix Acanthopanacis ( inline image), Caulis Impatientis ( inline image), Resina Draconis/Sanguis Draconis ( inline image), Fructus Cnidii ( inline image), Radix Gentiana Macrophyllae ( inline image), and Rhizoma Ligustici Chuanxiong ( inline image). Concomitant allergy to colophonium was found in most of these positive reactions. Reducing the concentration and simplifying the compositions of these components, as well as replacement with those of low allergenicity in CTM, such as Rhizoma Arisaematis ( inline image), Herba Lycopodii ( inline image), Radix Cyathulae Officinalis ( inline image), Rhizoma Pinelliae ( inline image), Radix Angelicae Dahuricae ( inline image), Herba Dendrobii ( inline image), Secretio Moschus ( inline image), and Stigmata Croci ( inline image), may be advocated. A precise labelling of the dosage of each component and the exact chemical compounds in CTM products could further improve the safety and therapeutic effects of CTM in the future.

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