The MOAHLFA index of irritant sodium lauryl sulfate reactions: first results of a multicentre study on routine sodium lauryl sulfate patch testing

  1. Wolfgang Uter1,*,
  2. Johannes Geier2,
  3. Detlef Becker3,
  4. Jochen Brasch4,
  5. Harald Löffler5,
  6. for the german contact dermatitis research group (dkg) and the information network of departments of dermatology (ivdk)†

Article first published online: 9 DEC 2004

DOI: 10.1111/j.0105-1873.2004.00458.x

Issue

Contact Dermatitis

Contact Dermatitis

Volume 51, Issue 5-6, pages 259–262, November 2004

Additional Information

How to Cite

Uter, W., Geier, J., Becker, D., Brasch, J., Löffler, H. and for the german contact dermatitis research group (dkg) and the information network of departments of dermatology (ivdk) (2004), The MOAHLFA index of irritant sodium lauryl sulfate reactions: first results of a multicentre study on routine sodium lauryl sulfate patch testing. Contact Dermatitis, 51: 259–262. doi: 10.1111/j.0105-1873.2004.00458.x

Author Information

  1. 1

    Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nürnberg, D-91054 Erlangen,

  2. 2

    Centre of the Information Network of Departments of Dermatology, Institute at the University of Göttingen, D-37075 Göttingen,

  3. 3

    Department of Dermatology, University of Mainz, D-55101 Mainz,

  4. 4

    Department of Dermatology, University of Kiel, D-24105 Kiel, and

  5. 5

    Department of Dermatology, Philipp-University, D-35033 Marburg, Germany

  1. †

    The following IVDK centres contributed data (in alphabetical order): Augsburg (A. Ludwig), Berlin Charité (T. Zuberbier, M. Worm), Dortmund (P. J. Frosch, C. Pirker, R. Herbst), Essen (U. Hillen), Freudenberg (Ch. Szliska), Graz (W. Aberer, B. Kränke), Halle (G. Gaber, D. Lübbe), Hamburg (M. Kiehn, R. Weßbecher), Heidelberg (U. Jappe, M. Hartmann), Kiel (J. Brasch), Krefeld (M. Lilie, A. Wallerand, S. Wassilew), Lübeck (J. Grabbe), Mainz (D. Becker), Marburg (I. Effendy, H. Löffler), München Schwabing (M. Agathos), Nürnberg (I. Müller), Osnabrück (S. M. John, H. J. Schwanitz, N. Schürer), Rostock (H. Heise), Ulm (P. Gottlöber, G. Staib, H. Pillekamp, R. Hinrichs).

*Wolfgang Uter, MD Department of Medical Informatics, Biometry and Epidemiology Friedrich Alexander-Universität Erlangen-Nürnberg Waldstr. 6 91054 Erlangen Germany Tel: +49 9131 8522720 Fax: +49 9131 8522721 e-mail: wolfgang.uter@rzmail.uni-erlangen.de

Publication History

  1. Issue published online: 9 DEC 2004
  2. Article first published online: 9 DEC 2004
  3. Accepted for publication 17 September 2004

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Keywords:

  • individual susceptibility;
  • irritant reaction;
  • patch testing;
  • sodium lauryl sulfate

In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25% and 0.5% aq. has been added to routine allergen patch tests to assess its properties as a convenient diagnostic indicator of individual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors of contact allergy to many allergens, e.g. summarized in the ‘MOAHLFA index’, the impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 participating patients. As a result of 2 logistic regression analyses with an irritant reaction to 0.25% and 0.5% SLS, respectively, as outcome, male sex was identified as a relatively weak but significant risk factor (OR 1.38), while age 40 years or older was an even weaker risk factor (OR 1.22 and 1.15, respectively). Upon detailed analysis, no clear age gradient could, however, be identified. 1-day exposure time almost halved the odds of an irritant SLS reaction. In conclusion, this type of SLS patch test can be regarded as robust, indicating individual irritability relatively independent from the individual factors analysed here.

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