Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair
Article first published online: 9 JUL 2004
Volume 200, Issue 1, pages 156–164, August 2004
How to Cite
Nick McElhinny, S. A. and Ramsden, D. A. (2004), Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair. Immunological Reviews, 200: 156–164. doi: 10.1111/j.0105-2896.2004.00160.x
- Issue published online: 9 JUL 2004
- Article first published online: 9 JUL 2004
Summary: The nonhomologous end-joining pathway is a major means for repairing double-strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the only efficient means for resolving DSB intermediates in V(D)J recombination, a lymphocyte-specific genome rearrangement required for assembly of antigen receptors. A role for polymerases in end-joining has been well established. They are a major factor in determining the character of repair junctions but, in contrast to ‘core’ end-joining factors, typically appear to have a subtle impact on the efficiency of end-joining. Recent work implicates several members of the Pol X family in end-joining and suggests surprising complexity in the control of how these different polymerases are employed in this pathway.