Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells
Article first published online: 6 JAN 2004
Volume 197, Issue 1, pages 147–160, January 2004
How to Cite
Allman, D., Srivastava, B. and Lindsley, R. C. (2004), Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunological Reviews, 197: 147–160. doi: 10.1111/j.0105-2896.2004.0108.x
- Issue published online: 6 JAN 2004
- Article first published online: 6 JAN 2004
Summary: Positive and negative selection of developing B cells is critical for generating a functional non-pathogenic B-cell repertoire. Newly formed B cells in the bone marrow or peripheral lymphoid system can be eliminated by one of several negative selection mechanisms or recruited through a poorly understood positive selection mechanism. In this review, we focus on the growing literature on the relevance of immature (transitional) peripheral B cells to the area of B-cell positive selection, with an emphasis on the notion that transitional B cells can be subdivided into several functionally distinct subpopulations. In this discussion, we consider the nature of these transitional B-cell subsets and their relevance to selection events that influence whether developing B cells eventually give rise to follicular versus marginal zone B cells. In addition, we attempt to initiate a resolution of current controversies surrounding transitional B-cell subsets and offer an alternative model of peripheral B-cell maturation and the follicular versus marginal zone decision.