Accessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8+ T-cell immune responses?
Version of Record online: 23 SEP 2005
Volume 207, Issue 1, pages 77–88, October 2005
How to Cite
Garbi, N., Tanaka, S., Van Den Broek, M., Momburg, F. and Hämmerling, G. J. (2005), Accessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8+ T-cell immune responses?. Immunological Reviews, 207: 77–88. doi: 10.1111/j.0105-2896.2005.00303.x
- Issue online: 23 SEP 2005
- Version of Record online: 23 SEP 2005
Summary: Assembly of major histocompatibility complex (MHC) class I molecules in the endoplasmic reticulum is a highly coordinated process that results in abundant class I/peptide complexes at the cell surface for recognition by CD8+ T cells and natural killer cells. During the assembly process, a number of chaperones and accessory molecules, such as transporter associated with antigen processing, tapasin, ER60, and calreticulin, assist newly synthesized class I molecules to facilitate loading of antigenic peptides and to optimize the repertoire of surface class I/peptide complexes. This review focuses on the relative importance of these accessory molecules for CD8+ T-cell responses in vivo and discusses reasons that may help explain why some CD8+ T-cell responses develop normally in mice deficient in components of class I assembly, despite impaired antigen presentation.