Mechanisms of MHC class I-restricted antigen processing and cross-presentation
Version of Record online: 23 SEP 2005
Volume 207, Issue 1, pages 145–157, October 2005
How to Cite
Cresswell, P., Ackerman, A. L., Giodini, A., Peaper, D. R. and Wearsch, P. A. (2005), Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunological Reviews, 207: 145–157. doi: 10.1111/j.0105-2896.2005.00316.x
- Issue online: 23 SEP 2005
- Version of Record online: 23 SEP 2005
Summary: In this review, we discuss recent data from our laboratory that address two aspects of major histocompatibility complex (MHC) class I-restricted antigen processing. First, we consider the nature of the peptide-loading complex, which is the assembly of proteins in the endoplasmic reticulum (ER) into which newly synthesized MHC class I-β2 microglobulin (β2m) heterodimers are incorporated, and the mechanisms involved in MHC class I assembly and peptide loading that are facilitated by the peptide-loading complex. Second, we discuss mechanisms of cross-presentation, the phenomenon whereby extracellular and luminal protein antigens can be processed by antigen-presenting cells, particularly dendritic cells, and presented by MHC class I molecules to CD8+ T cells. The focus of the discussion is mainly on the human MHC class I system.