Microarray-based understanding of normal and malignant plasma cells
Version of Record online: 28 MAR 2006
Volume 210, Issue 1, pages 86–104, April 2006
How to Cite
De Vos, J., Hose, D., Rème, T., Tarte, K., Moreaux, J., Mahtouk, K., Jourdan, M., Goldschmidt, H., Rossi, J.-F., Cremer, F. W. and Klein, B. (2006), Microarray-based understanding of normal and malignant plasma cells. Immunological Reviews, 210: 86–104. doi: 10.1111/j.0105-2896.2006.00362.x
- Issue online: 28 MAR 2006
- Version of Record online: 28 MAR 2006
Summary: Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.