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Microarray-based understanding of normal and malignant plasma cells

Authors


* Professor Bernard Klein
IRB
Research Institute for Biotherapy
Hôpital Saint-Eloi
80 rue Augustin Fliche
34295 Montpellier Cedex 5
France
Fax: 33 467 33 01 13
E-mail: klein@montp.inserm.fr

Abstract

Summary:  Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.

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