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Transcription factors that regulate memory in humoral responses

Authors

  • Kathryn Calame

    Corresponding author
    1. Departments of Microbiology and Biochemistry & Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY, USA.
      Kathryn Calame
      Departments of Microbiology and Biochemistry & Molecular Biophysics
      Columbia University College of Physicians and Surgeons
      701 W 168th St.
      New York, NY 10032
      USA
      Tel.: +1 212 305 3504
      Fax: +1 212 305 1468
      E-mail: klc1@columbia.edu
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Kathryn Calame
Departments of Microbiology and Biochemistry & Molecular Biophysics
Columbia University College of Physicians and Surgeons
701 W 168th St.
New York, NY 10032
USA
Tel.: +1 212 305 3504
Fax: +1 212 305 1468
E-mail: klc1@columbia.edu

Abstract

Summary:  At least three types of B lymphocytes are important for providing memory in a humoral immune response: ‘classical’ memory cells that do not secrete immunoglobulin (Ig), long-lived plasma cells (LLPCs) in the bone marrow, and ‘innate-like’ B-1 cells. In this review, our work on B-lymphocyte-induced maturation protein-1 (Blimp-1), a critical regulator of terminal B-cell differentiation, is discussed in the context of current knowledge of all transcriptional controls that regulate these three types of B cells. Blimp-1 is not required for formation of memory cells, but it is required for them to progress toward becoming plasma cells. Blimp-1 is required for Ig secretion in plasma cells and in B-1 cells. Induction of the activator X-box-binding protein-1 and formation of µ-secreted mRNA depend on Blimp-1 in both cell types. Finally, even after their formation, LLPCs in the bone marrow continue to require Blimp-1 for their maintenance.

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