Developing and maintaining protective CD8+ memory T cells
Article first published online: 13 JUN 2006
Volume 211, Issue 1, pages 146–153, June 2006
How to Cite
Williams, M. A., Holmes, B. J., Sun, J. C. and Bevan, M. J. (2006), Developing and maintaining protective CD8+ memory T cells. Immunological Reviews, 211: 146–153. doi: 10.1111/j.0105-2896.2006.00389.x
- Issue published online: 13 JUN 2006
- Article first published online: 13 JUN 2006
Summary: A critical aim of vaccine-related research is to identify the mechanisms by which memory T cells are formed and maintained over long periods of time. In recent years, we have designed experiments aimed at addressing two key questions: (i) what are the factors that maintain functionally responsive CD8+ memory cells over long periods of time, and (ii) what are the signals during the early stages of infection that drive the differentiation of long-lived CD8+ memory T cells? We have identified a role for CD4+ T cells in the generation of CD8+ T-cell-mediated protection from secondary challenge. While CD4+ T cells appear to play a role in the programme of CD8 memory, we find that they are also required for the long-term maintenance of CD8+ memory T-cell numbers and function. This property is independent of CD40–CD40L interactions, and we propose a role for CD4+ T cells in maintaining the ability of CD8+ memory T cells to respond to interleukin-7 (IL-7) and IL-15. By manipulating both the time course of infection and the timing of antigen presentation to newly recruited CD8+ T cells, we also demonstrate that the programming of effector and memory potential are at least partially distinct processes.