Development, trafficking, and function of memory T-cell subsets

Authors


Leo Lefrançois
University of Connecticut Health Center
Department of Immunology
263 Farmington Ave.
Farmington, CT 06107
USA
Tel.: +1 860 6793242
Fax: +1 860 6791868
E-mail: llefranc@neuron.uchc.edu

Abstract

Summary:  The precise mechanisms that govern memory T-cell lineage commitment during an immune response continue to be the subject of intense scrutiny. The existence of memory T-cell subsets defined by location, function, and phenotype adds an additional layer of complexity to the overall memory T-cell population. In this review, the integration of memory subset development and migration and the functional consequences of specific tissue localization are discussed.

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