Th1 memory: implications for vaccine development
Article first published online: 13 JUN 2006
Volume 211, Issue 1, pages 58–66, June 2006
How to Cite
Foulds, K. E., Wu, C.-y. and Seder, R. A. (2006), Th1 memory: implications for vaccine development. Immunological Reviews, 211: 58–66. doi: 10.1111/j.0105-2896.2006.00400.x
- Issue published online: 13 JUN 2006
- Article first published online: 13 JUN 2006
Summary: T-helper 1 (Th1) cells play a critical role, via interferon-γ (IFN-γ) production, in mediating intracellular killing against a variety of infectious pathogens. Thus, understanding the regulation of Th1 responses could provide better insight into vaccine design for infections requiring Th1 immunity. The cellular and molecular mechanisms that control the induction of Th1 effector cells have been well characterized. More recently, there has been substantial progress in furthering our understanding of the factors that regulate the development of Th1 memory cells. It is clear that Th1 responses are functionally heterogeneous, as defined by their ability to produce IFN-γ. Furthermore, this heterogeneity has profound implications for the capacity of distinct lineages of Th1 cells to develop into memory cells. This review emphasizes the mechanisms controlling the differentiation of naïve CD4+ T cells into effector and then memory cells in a progressive manner. It highlights the importance of IFN-γ as a positive regulator for inducing Th1 responses but a negative regulator for sustaining Th1 effector cells. In conclusion, we discuss how this current understanding of Th1 differentiation will inform vaccine design and better define immune correlates of protection.