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The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology

Authors


David M Sansom
MRC Centre for Immune Regulation
University of Birmingham Medical School
Vincent Drive
Birmingham B15 2TT
UK
Tel.: +44 121 414 2268
Fax: +44 121 141 3599
E-mail: D.M.Sansom@bham.ac.uk

Abstract

Summary:  The profound influence of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) on T-cell immunity has been known for over a decade, yet the precise roles played by these molecules still continue to emerge. Initially viewed as molecules that provide cell-intrinsic costimulatory and inhibitory signals, recent evidence suggests that both CD28 and CTLA-4 are also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Tregs). Here we review the main features of the CD28 and CTLA-4 system and examine how these impact upon Treg biology.

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