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DC subsets in positive and negative regulation of immunity


Muriel Moser
Laboratoire de Physiologie Animale
Université Libre de Bruxelles
Rue des Pr Jeener et Brachet, 12
6041 Gosselies, Belgium
Tel.: + 32 2 650 9863
Fax: + +32 2 650 9860


Summary:  Since their discovery in 1973, dendritic cells (DCs) have gained strong interest from immunologists because of their unique capacity to sensitize naive T cells. There is now strong evidence that cells of the dendritic family not only control immunity but also regulate responses to self and non-self, thereby avoiding immunopathology. These two complementary functions are critical to ensure the integrity of the organism in an environment full of antigens. How DCs display these opposite functions is still intriguing. Here, we review the role of DC subsets in the regulation of T-helper responses in vivo.