A Triglyceride/High-Density Lipoprotein Ratio ≥3.5 Is Associated With an Increased Burden of Coronary Artery Disease on Cardiac Catheterization

Authors

  • Robert Ostfeld MD, MS,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 1 Disha Mookherjee MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 1 Michael Spinelli MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 1 Dvorah Holtzman MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 1 Abu Shoyeb MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 2 Michael Schaefer MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 1 Sanjay Doddamani MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • 1 Daniel Spevack MD,

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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  • and 1 Yunling Du PhD 3

    1. From the Division of Cardiovascular Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;1Memorial Sloan Kettering Cancer Center, New York, NY;2 and the Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY3
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Robert Ostfeld, MD, MS, Montefiore Medical Center, 3400 Bainbridge Avenue, Heart Center — 7th Floor, Bronx, NY 10467-2490
E-mail: rostfeld@montefiore.org

Abstract

An elevated triglyceride (TG)/high-density lipoprotein (HDL) ratio has been described as a predictor of insulin resistance and cardiovascular events. We evaluated whether a TG/HDL ratio ≥3.5 was associated with the burden of coronary artery disease (CAD) on cardiac catheterization. A retrospective chart review of 156 consecutive adults presenting to the Montefiore Medical Center Emergency Department with symptoms of unstable angina and no known history of CAD who underwent cardiac catheterization as part of their index hospitalization was performed. TG and HDL data were available in 100 patients within 6 months prior to admission and no more than 24 hours after presentation. A priori, a burden of CAD score was developed. On multivariate analysis, a TG/HDL ratio ≥3.5 was associated with the burden of CAD (odds ratio, 2.87; 95% confidence interval, 1.03–7.96; p=0.04). Further study is warranted.

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