• 1
    Curotto de Lafaille MA, Lafaille JJ. CD4+ regulatory T cells in autoimmunity and allergy. Curr Opin Immunol 2002;14: 7718.
  • 2
    Shevach EM. Regulatory T cells in autoimmunity. Annu Rev Immunol 2000;18: 42349.
  • 3
    Sakaguchi S, Sakaguchi N, Asano M et al. Immunologic self-tolerance maintained by activated T cells expressing Il−2 receptor alpha-chains (CD25). Breakdown of single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155: 115164.
  • 4
    Asano M, Toda M, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation. J Exp Med 1996;184: 38796.
  • 5
    Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T-cell activation in vitro by inhibiting interlukin-2 production. J Exp Med 1998;188: 28796.
  • 6
    Takahashi T, Kuniyasu Y, Toda M et al. Immunologic self-tolerance maintained by CD4+CD25+ naturally anergic and suppressive T cells. Int Immunol 1998;10: 196980.
  • 7
    Reed S, Mauze S, Asseman C, Bean A, Coffman R, Powrie F. CD38+CD45Rblow T cells: a population of T cells with immune regulatory activities. Eur J Immunol 1998;28: 345347.
  • 8
    Nishizuka Y, Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969;166: 7535.
  • 9
    Kojima A, Tanaka-Kojima Y, Sakakura T et al. Prevention of post-thymectomy autoimmune thyroidtis in mice. Lab Invest 1976;34: 6015.
  • 10
    Kojima A, Taguchi O, Nishizuka Y. Experimental production of possible autoimmune gastritis followed by macrocytic anemia in athymic nude mice. Lab Invest 1980;42: 38795.
  • 11
    Sakaguchi S, Takahashi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocyte damage after adoptive transfer. J Exp Med 1982;156: 156576.
  • 12
    Sakaguchi S, Takahasi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 1982;156: 157786.
  • 13
    Ng WF, Duggan PJ, Ponchel F et al. Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells. Blood 2001;98: 273644.
  • 14
    Diekmann D, Plottner H, Berchtold S et al. Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood J Exp Med 2001;193: 130311.
  • 15
    Baecher-Allen C, Brown JA, Feeman GJ et al. CD4+CD25+ regulator cells in human peripheral blood. J Immunol 2001;167: 124553.
  • 16
    Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001;193: 128594.
  • 17
    Stephens LA, Mottet C, Mason D. Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity. Eur J Immunol 2001;31: 124754.
  • 18
    Bombardier C, Gladman DD, Urowitz MB et al. Committee on prognosis studies in SLE. Derivation of the SLEDAI. Arthritis Rheum 1992;35: 63040.
  • 19
    Kunitasu Y, Takahashi T, Itoh M, Shimizu J, Toda G, Sakaguchi S. Naturally anergic and suppressive CD4+CD25+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol 2000;12: 114555.
  • 20
    Thomton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998;188: 28796.
  • 21
    Asseman C, Mauze S, Leach MW et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999;190: 9951004.
  • 22
    Powrie F, Carlino J, Leach MW et al. A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RblowCD4+ T cells. J Exp Med 1996;183: 266974.
  • 23
    Chen Y, Kuchroo VK, Inobe J et al. Regulatory T cell colonies induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265: 123740.
  • 24
    Piccirillo CA, Shevach EM. Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 2001;167: 113740.
  • 25
    Takahashi T, Tagami T, Yamazaki S et al. Immunologic self-tolerance maintained by CD4+CD25+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000;192: 30310.
  • 26
    Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD4+CD25+ regulatory cells that control intestinal role inflammation. J Exp Med 2000;192: 295302.
  • 27
    Bystry RS, Aluvihare V, Welch KA et al. B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2001;2: 112632.
  • 28
    Seo SJ, Fields ML, Buckler JL et al. The impact of T helper and T regulatory cells on the regulation of anti-double-strand DNA B cells. Immunity 2002;16: 53546.
  • 29
    Cao D, Malmstrom V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25 bright CD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003;33: 21533.