• 1
    Mims CA. Pathogenesis of Infectious Disease. London: Academic Press, 1987.
  • 2
    Zinkernagel RM. Uncertainties – discrepancies in immunology. Immunol Rev 2002;185: 10325.
  • 3
    Karrer U, Althage A, Odermatt B et al. On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(–)/–) mutant mice. J Exp Med 1997;185: 215770.
  • 4
    Frazer IH, Thomas R, Zhou J et al. Potential strategies utilised by papillomavirus to evade host immunity. Immunol Rev 1999;168: 13142.
  • 5
    Cohn M, Langman RE. The protection: the unit of humoral immunity selected by evolution. Immunol Rev 1990;115: 1147.
  • 6
    Schwartz RH. T cell clonal anergy. Curr Opin Immunol 1997;9: 3517.
  • 7
    Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12: 9911045.
  • 8
    Ohashi PS, Oehen S, Buerki K et al. Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991;65: 30517.
  • 9
    Ochsenbein AF, Sierro S, Odermatt B et al. Roles of tumour localization, second signals and cross priming in cytotoxic T cell induction. Nature 2001;411: 105864.
  • 10
    Ochsenbein AF, Pinschewer DD, Odermatt B, Ciurea A, Hengartner H, Zinkernagel RM. Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design. J Immunol 2000;164: 6296302.
  • 11
    Silvers WK, Elkins WL, Quimby FW. Cellular basis of tolerance in neonatally induced mouse chimeras. J Exp Med 1975;142: 13125.
  • 12
    Karjalainen K. High sensitivity, low affinity – paradox of T-cell receptor recognition. Curr Opin Immunol 1994;6: 912.
  • 13
    Krummel MF, Davis MM. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol 2002;14: 6674.
  • 14
    Speiser DE, Kyburz D, Stubi U, Hengartner H, Zinkernagel RM. Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection. J Immunol 1992;149: 97280.
  • 15
    Bevan MJ. Antigen recognition. Class discrimination in the world of immunology. Nature 1987;325: 1924.
  • 16
    Carbone FR, Bevan MJ. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med 1990;171: 37787.
  • 17
    Bachmann MF, Rohrer UH, Steinhoff U et al. T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice. Eur J Immunol 1994;24: 296673.
  • 18
    Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998;392: 869.
  • 19
    Sigal LJ, Crotty S, Andino R, Rock KL. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 1999;398: 7780 [see comments].
  • 20
    Freigang S, Egger D, Bienz K, Hengartner H, Zinkernagel RM. Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming. Proc Natl Acad Sci USA 2003;100: 1347782.
  • 21
    Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 2002;99: 3518.
  • 22
    Kündig TM, Bachmann MF, DiPaolo C et al. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 1995;268: 13437.
  • 23
    Bach JF. One or several thymic hormones? Recent Results Cancer Res 1980;75: 1069.
  • 24
    Aiuti F, Businco L, Fiorilli M et al. Thymopoietin pentapeptide treatment of primary immunodeficiencies. Lancet 1983;1: 5514.
  • 25
    Bevan MJ. In a radiation chimera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 1977;269: 4178.
  • 26
    Zinkernagel RM, Callahan GN, Klein J, Dennert G. Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature 1978;271: 2513.
  • 27
    Longo DL, Schwartz RH. T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Nature 1980;287: 446.
  • 28
    Matzinger P, Mirkwood G. In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type. J Exp Med 1978;148: 8492.
  • 29
    Zinkernagel RM & Althage A. On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells. Proc Natl Acad Sci USA 1999;96: 80927.
  • 30
    Martinic MM, Rulicke T, Althage A et al. Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC. Proc Natl Acad Sci USA 2003;100: 18616.
  • 31
    Bannish G, Fuentes-Panana EM, Cambier JC, Pear WS, Monroe JG. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med 2001;194: 158396.
  • 32
    Heltemes LM, Manser T. Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development. J Immunol 2002;169: 128392.
  • 33
    Moskophidis D, Lechner F, Pircher HP, Zinkernagel RM. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 1993;362: 75861.
  • 34
    Hotchin J. The biology of lymphocytic choriomeningitis infection: virus induced immune disease. Cold Spring Harb Symp Quant Biol 1962;27: 47999.
  • 35
    Shevach EM. CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2: 389400.
  • 36
    Chatenoud L, Salomon B, Bluestone JA. Suppressor T cells – they're back and critical for regulation of autoimmunity! Immunol Rev 2001;182: 14963.
  • 37
    Sakaguchi S, Sakaguchi N, Shimizu J et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001;182: 1832.
  • 38
    Mitchison NA. The carrier effect in the secondary response to hapten-protein conjugates. V. Use of antilymphocyte serum to deplete animals of helper cells. Eur J Immunol 1971;1: 6875.
  • 39
    Katz DH, Benacerraf B. The regulatory influence of activated T cells on B cell responses to antigen. Adv Immunol 1972;15: 194.
  • 40
    Feldmann M, Howard JG, Desaymard C. Role of antigen structure in the discrimination between tolerance and immunity by b cells. Transplant Rev 1975;23: 7897.
  • 41
    Dintzis HM, Dintzis RZ. Antigens as immunoregulators. Immunol Rev 1990;115: 24350.
  • 42
    Bachmann MF, Rohrer UH, Kuendig TM, Buerki K, Hengartner H, Zinkernagel RM. The influence of antigen organization on B cell responsiveness. Science 1993;262: 144851.
  • 43
    Moller G. One non-specific signal triggers b lymphocytes. Transplant Rev 1975;23: 12637.
  • 44
    Nemazee D, Russell D, Arnold B et al. Clonal deletion of autospecific B lymphocytes. Immunol Rev 1991;122: 11732.
  • 45
    Goodnow CC. B cell tolerance. Curr Opin Immunol 1992;4: 70310.
  • 46
    Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, Zinkernagel RM. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000;288: 22226.
  • 47
    Fagarasan S, Kinoshita K, Muramatsu M, Ikuta K, Honjo T. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature 2001;413: 63943.
  • 48
    Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996;272: 5460.
  • 49
    Dutton RW, Swain SL, Bradley LM. The generation and maintenance of memory T and B cells. Immunol Today 1999;20: 2913.
  • 50
    Zinkernagel RM, Bachmann MF, Kuendig TM, Oehen S, Pircher HP, Hengartner H. On immunological memory. Annu Rev Immunol 1996;14: 33367.
  • 51
    Gray D, Sprent J. Immunological memory. Curr Top Microbiol Immunol 1990;159: 1138.
  • 52
    Zinkernagel RM. Maternal antibodies, childhood infections and autoimmune diseases. N Engl J Med 2001;345: 13315.
  • 53
    Henrot A. Mother-infant and indirect transmission of HSV infection: treatment and prevention. Ann Dermatol Venereol 2002;129: 53349.
  • 54
    Roizman B, Whitley RJ. The nine ages of herpes simplex virus. Herpes 2001;8: 237.
  • 55
    Mackaness GB. The relationship of delayed hypersensitivity to acquired cellular resistance. Br Med Bull 1967;23: 524.
  • 56
    Mackaness GB. Resistance to intracellular infection. J Infect Dis 1971;123: 43945.
  • 57
    Bloom BR, Murray CJ. Tuberculosis: commentary on a re-emergent killer. Science 1992;257: 105564
  • 58
    Kaufmann SH. How can immunology contribute to the control of tuberculosis? Nat Rev Immunol 2001;1: 2030.
  • 59
    Brambell RWR. The Transmission of Immunity from Mother to Young. Amsterdam: North Holland Publishers Corp., 1970.
  • 60
    Nathanson N. Epidemiology. In: FieldsBN, KnipeDM, eds. Virology, 2nd edn. New York: Raven Press, 1990, 26791.