Three Children with CD30+ Cutaneous Anaplastic Large Cell Lymphomas Bearing the t(2;5)(p23;q35) Translocation
Version of Record online: 24 MAY 2004
Volume 21, Issue 3, pages 212–217, May 2004
How to Cite
Hinshaw, M., Trowers, A. B., Kodish, E., Kuerbitz, S., Shurin, S. and Wood, G. S. (2004), Three Children with CD30+ Cutaneous Anaplastic Large Cell Lymphomas Bearing the t(2;5)(p23;q35) Translocation. Pediatric Dermatology, 21: 212–217. doi: 10.1111/j.0736-8046.2004.21304.x
- Issue online: 24 MAY 2004
- Version of Record online: 24 MAY 2004
Abstract: Since its discovery in CD30+ anaplastic large cell lymphomas, the t(2;5)(p23;q35) translocation has shown a high degree of association with nodal disease, younger patient age, and better prognosis. Furthermore, primary cutaneous CD30+ anaplastic large cell lymphomas rarely manifests the t(2;5) translocation. We present three cases of this disease that occurred in children, bore the t(2;5) translocation, and had excellent outcomes, but presented cutaneously. Two of these lesions were primary skin lymphomas. Review of the available literature in conjunction with these three cases suggests that the t(2;5) translocation may be more strongly associated with younger patient age and favorable outcomes rather than nodal versus cutaneous site of presentation.