Neurodevelopment of children born very preterm and free of severe disabilities: the Nord-Pas de Calais Epipage cohort study
Article first published online: 28 JAN 2010
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica
How to Cite
Charkaluk, M., Truffert, P., Fily, A., Ancel, P., Pierrat, V. and Epipage study group (2010), Neurodevelopment of children born very preterm and free of severe disabilities: the Nord-Pas de Calais Epipage cohort study. Acta Paediatrica. doi: 10.1111/j.0803-5253.2010.01695.x
- Issue published online: 28 JAN 2010
- Article first published online: 28 JAN 2010
- Received 5 October 2009; revised 22 November 2009; accepted 23 December 2009.
- Follow-up studies;
- Neurodevelopmental outcome;
- Premature infant;
- Social-environmental risk factors
Aim: To describe the development of very preterm children free of cerebral palsy or severe sensory impairment in the domains of gross and fine motor functions, language and sociability at a corrected age of 2 years; to identify factors associated with performances in each domain.
Methods: A total of 347 children born in 1997 before 33 weeks of gestation, part of the EPIPAGE population-based cohort study, had their psychomotor development assessed with the Brunet-Lezine scale.
Results: The study population had a mean gestational age of 30.1 ± 2.0 weeks. Lower developmental quotients (DQ) were observed in the study group compared to the reference sample (96 ± 13 vs 104 ± 8, p < 0.01). Fine motor function, language and sociability were all affected with a p value <0.01. Multivariate analysis showed that duration of intubation and parents’ educational and occupational levels were the only variables significantly related to each developmental domain (p < 0.01).
Conclusions: Children very preterm and free of severe disabilities had mild delays in multiple areas of development. The mechanisms by which neonatal factors played a role need further investigation. However socioeconomic status had a great impact on development and our results underline the need for improved support of socioeconomically disadvantaged parents after a preterm birth.