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HYPERTENSION IN HEMODIALYSIS PATIENTS: Volume-Independent Mechanisms of Hypertension in Hemodialysis Patients: Clinical Implications


Peter J. Blankestijn, MD, Department of Nephrology, Room F03.226, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The Netherlands, or e-mail:


The renin-angiotensin and sympathetic nervous systems are often activated in hemodialysis (HD) patients; the pathogenesis of this condition is discussed. Medications aimed at reducing renin and sympathetic activity may improve the cardiovascular prognosis, independent of its effect on blood pressure. This knowledge has important implications for the choice of treatment in HD patients.