Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome

  1. Caroline Arber,
  2. Andreas Buser,
  3. Dominik Heim,
  4. Alois Gratwohl,
  5. André Tichelli,
  6. Jakob R. Passweg

Article first published online: 5 JAN 2006

DOI: 10.1111/j.0902-4441.2005.00593.x

Issue

European Journal of Haematology

European Journal of Haematology

Volume 76, Issue 3, pages 255–257, March 2006

Additional Information

How to Cite

Arber, C., Buser, A., Heim, D., Gratwohl, A., Tichelli, A. and Passweg, J. R. (2006), Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome. European Journal of Haematology, 76: 255–257. doi: 10.1111/j.0902-4441.2005.00593.x

Author Information

  1. Hematology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland

*Jakob R Passweg, Hematology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, CH- 4031 Basel, Switzerland Fax: ++ 41 61 265 4450 e-mail: passwegj@uhbs.ch

Publication History

  1. Issue published online: 5 JAN 2006
  2. Article first published online: 5 JAN 2006
  3. Accepted for publication 12 September 2005

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Abstract:  A 64-yr-old patient with myelodysplastic syndrome (MDS), with refractory cytopenia with multilineage dysplasia subtype following chloramphenicol exposure received immunosuppressive treatment with antithymocyte globulin and cyclosporine (CsA). Complete remission was achieved and CsA was tapered after 2.5 yr. Shortly after CsA withdrawal, the patient relapsed with thrombocytopenia but responded to restoration of CsA. This case illustrates that immune-mediated mechanisms of cytopenia in MDS may be dependent on continued immunosuppressive treatment similar to aplastic anemia.

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