Cefotaxime as the potential cause of transient acquired von Willebrand syndrome


Haj MD, Arthur Bloom Haemophilia Center and Singleton Hospital, Swansea-Wales, Department of Haematology, Cardiff, CF14 4XN, UK
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Abstract:  Acquired von Willebrand syndrome (AvWS) is a relatively rare bleeding disorder. It has been reported in association with myeloproliferative disorders, autoimmune diseases, plasma cell dyscrasias and certain drugs. Cefotaxime is a third generation cephalosporin widely used for surgical prophylaxis and as empirical treatment of bacterial meningitis. We report a case of a transient AvWS in association with cefotaxime therapy.