Left hemisphere motor facilitation in response to manual action sounds

Authors

  • Lisa Aziz-Zadeh,

    1. Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, UCLA, 660 Charles E. Young Dr. South, Los Angeles, CA90095–7085, USA
    2. Departmentof Psychology, University of California at Los Angeles, Los Angeles, CA 90095, USA
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  • Marco Iacoboni,

    1. Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, UCLA, 660 Charles E. Young Dr. South, Los Angeles, CA90095–7085, USA
    2. Department of Psychiatry and Biobehavioural Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    3. Brain Research Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
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  • Eran Zaidel,

    1. Departmentof Psychology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    2. Brain Research Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
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  • Stephen Wilson,

    1. Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, UCLA, 660 Charles E. Young Dr. South, Los Angeles, CA90095–7085, USA
    2. Neuroscience Interdepartmental Program at UCLA, Los Angeles, CA, USA
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  • John Mazziotta

    1. Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, UCLA, 660 Charles E. Young Dr. South, Los Angeles, CA90095–7085, USA
    2. Department of Psychiatry and Biobehavioural Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    3. Brain Research Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    4. Departments of Neurology, Pharmacology and Radiological Sciences at UCLA, Los Angeles, CA, USA
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: Dr Lisa Aziz-Zadeh, as above.
E-mail: lazadeh@loni.ucla.edu

Abstract

Previous studies indicate that the motor areas of both hemispheres are active when observing actions. Here we explored how the motor areas of each hemisphere respond to the sounds associated with actions. We used transcranial magnetic stimulation (TMS) to measure motor corticospinal excitability of hand muscles while listening to sounds. Sounds associated with bimanual actions produced greater motor corticospinal excitability than sounds associated with leg movements or control sounds. This facilitation was exclusively lateralized to the left hemisphere, the dominant hemisphere for language. These results are consistent with the hypothesis that action coding may be a precursor of language.

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