FATTY LIVER PERSISTING FOR UP TO 33 YEARS

A Follow-up of the Iversen/Roholm Liver Biopsy Material

Authors

  • M. Hilden,

    1. Deparment of Medicine B, Bispebjerg Hospital, and the Departments of Medicine II and III, and Pathological Anatomy, Kommunehospitalet, Copenhagen, Denmark
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  • E. Juhl,

    1. Deparment of Medicine B, Bispebjerg Hospital, and the Departments of Medicine II and III, and Pathological Anatomy, Kommunehospitalet, Copenhagen, Denmark
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  • Å. Chr. Thomsen,

    1. Deparment of Medicine B, Bispebjerg Hospital, and the Departments of Medicine II and III, and Pathological Anatomy, Kommunehospitalet, Copenhagen, Denmark
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  • P. Christoffersen

    1. Deparment of Medicine B, Bispebjerg Hospital, and the Departments of Medicine II and III, and Pathological Anatomy, Kommunehospitalet, Copenhagen, Denmark
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Abstract

Abstract. Re-evaluation of 890 consecutive liver biopsy specimens from the period 1938–56 has been done and fatty liver diagnosed in 59 patients. A follow-up examination was performed on 58 of these patients, their time of observation in respect to long-time prognosis of fatty liver varying from 16–33 years, half of the patients being alcoholics. Evaluation of the liver was done on the basis of microscopy from repeated biopsy or autopsy (18 cases), on postmortem gross examination (19 cases), on clinical and laboratory findings (4 cases) or on death certificate (17 cases). In the follow-up period cirrhosis of the liver was diagnosed in two patients only, one being an alcoholic. A certain degree of fatty liver was shown in nearly all cases in which histology had been performed. Our results support the hypothesis that steatosis and cirrhosis represent the various forms of response from the liver rather than coherent stages in the development of alcoholic liver damage.

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