Biochemical Variables Related to Calcium Metabolism in Epileptics

Authors

  • John F. Dymling,

    1. Department of Endocrinology, Malmö General Hospital, Malmö
    2. Department of Orthopaedic Surgery, University Hospital, University of Lund, Lund, Sweden
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  • Lars Lidgren,

    1. Department of Endocrinology, Malmö General Hospital, Malmö
    2. Department of Orthopaedic Surgery, University Hospital, University of Lund, Lund, Sweden
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  • Anders Wallöe M.D.

    Corresponding author
    1. Department of Endocrinology, Malmö General Hospital, Malmö
    2. Department of Orthopaedic Surgery, University Hospital, University of Lund, Lund, Sweden
      Department of Orthopaedic Surgery, University Hospital, S-22185 Lund, Sweden.
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Department of Orthopaedic Surgery, University Hospital, S-22185 Lund, Sweden.

Abstract

ABSTRACT. Five biochemical variables, S-Ca, U- Ca, S-P, U-P and S-ALP, all involved in calcium metabolism, have been investigated in 86 epileptics on long-term medication. We found hypocalciuria in half of the epileptics and increased S-ALP in one third. In contrast to earlier reports there was no hypocalcemia, whereas hypercalcemia was found in 7 epileptics. We have previously reported a high frequency of fractures in these epileptics. An increased fracture rate was found in the 13 epileptics with both hypocalciuria and increased S-ALP, indicating osteomalacia.

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