Fractional Intestinal Calcium Absorption in Epileptics on Anticonvulsant Therapy.

Short-Term Effect of 1,25-Dihydroxycholecalciferol and 25-Hydroxycholecalciferol

Authors

  • Leif Mosekilde,

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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  • Hans Hvid Hansen,

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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  • Merete Sanvig Christensen,

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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  • Birger Lund,

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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  • Ole Helmer Sørensen,

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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  • Flemming Melsen,

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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  • Anthony W. Normany

    1. Neurological and Nuclear Medicine Department, Århus Kommunehospital, Copenhagen, Denmark
    2. Medical Department III and University Institute of Pathology, Århus Amtssygehus, Copenhagen, Denmark
    3. Institute of Pharmacology, University of Århus, Department of Medicine E. Frederiksberg Hospital, Copenhagen, Denmark
    4. Department of Medicine F, Herley Hospital, Copenhagen, Denmark
    5. Department of Biochemistry, University of California, Riverside, USA
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Abstract

ABSTRACT. Fractional intestinal 47Ca calcium absorption (α) in 12 epileptic outpatients receiving chronic high-dose anticonvulsant therapy was reduced (p>0.05) compared to 12 matched normal controls. Six of the epileptics were treated orally with 0.5 μg of 1,25-dihydroxycholecalciferol (1,25-DHCC) per day and six with 10 μg of 25-hydroxycholecalciferol (25-HCC) per day for 10 days. The α was determined before and after treatment and compared with the effect of 0.5 μg of 1,25-DHCC per day given for 10 days to 6 controls. An increase of the same order in α was found in all groups (p>0.05). No changes were observed in the serum levels of calcium, phosphorus, alkaline phosphatase or iPTH during treatment. Urinary calcium excretion was low in the epileptic patients and rose during treatment. The investigation demonstrates that the sensitivity of the intestine to 1,25-DHCC is normal in epileptic patients on anticonvulsant therapy and that 1,25-DHCC and 25- HCC in the given doses had an equal effect on the reduced intestinal calcium absorption.

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