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Serum Concentration of Cystatin C, Factor D and β2-Microglobulin as a Measure of Glomerular Filtration Rate

Authors

  • A. GRUBB,

    1. Department of Clinical Chemistry, Malmö General Hospital, Malmö, and Departments of Nephrology and Immunology, University Hospital, Lund, Sweden
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  • O. SIMONSEN,

    1. Department of Clinical Chemistry, Malmö General Hospital, Malmö, and Departments of Nephrology and Immunology, University Hospital, Lund, Sweden
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  • G. STURFELT,

    1. Department of Clinical Chemistry, Malmö General Hospital, Malmö, and Departments of Nephrology and Immunology, University Hospital, Lund, Sweden
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  • L. TRUEDSSON,

    1. Department of Clinical Chemistry, Malmö General Hospital, Malmö, and Departments of Nephrology and Immunology, University Hospital, Lund, Sweden
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  • H. THYSELL

    Corresponding author
    1. Department of Clinical Chemistry, Malmö General Hospital, Malmö, and Departments of Nephrology and Immunology, University Hospital, Lund, Sweden
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Department of Nephrology, University Hospital of Lund, S-221 85 Lund, Sweden

Abstract

ABSTRACT. Serum concentrations of creatinine and of the three low molecular weight (LMW) proteins cystatin C, factor D of the complement system and β2-microglobulin were measured in 135 consecutive patients, whose glomerular filtration rates (GFR) were determined by Cr-EDTA. In the total patient series, the reciprocals of S-creatinine and S-cystatin C were numerically and, in males, significantly more closely correlated to GFR than the reciprocals of S-factor D. The reciprocals of β2-microglobulin showed a weaker correlation to GFR than those of the other three substances. The calculated glomerular elimination rates of creatinine, cystatin C and factor D were normally distributed, in contrast to those of β2-microglobulin. According to data presented so far, cystatin C seems to be the LMW protein of first choice when GFR is to be estimated by measuring the plasma concentration of a LMW protein.

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