Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application

Authors


Dr Christian Behl
Institute for Physiological Chemistry and Pathobiochemistry
Johannes Gutenberg-University Mainz
Medical School
55099 Mainz
Germany
Tel.: +49 (0) 613 139 25 890
Fax: +49 (0) 613 139 25 792
E-mail: cbehl@uni-mainz.de

Summary

To date, various strategies have been developed in order to prevent or to slow down the progression of Alzheimer's disease (AD). Despite the medical need for an effective therapeutic treatment of AD, progress towards this goal is painstakingly slow. Although AD is the most common neurodegenerative disorder and a large amount of primary basic and clinical research has been performed already, it appears very difficult to identify appropriate targets, which would promise fast, effective and safe strategies to combat the disease onset and progression. In this review, we present some of clinically applied treatment options, which may improve AD symptoms for a short period but so far lack the ability to prevent or halt this devastating disease. Additionally, we summarize some of the experimental approaches in AD therapy, which might lead to the development of more promising drugs in the future.

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