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Elimination of CD4+CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB × NZW F1 mice


T. Hayashi
Laboratory of Veterinary Pathology
Faculty of Agriculture
Yamaguchi University
1677-1, Yoshida
Yamaguchi 753-8515
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The role of CD4+CD25+ T cell in glomerulonephritis (GN) development during the preactive phase was investigated in autoimmune-prone female NZB × NZW F1 (B/WF1) mice. The administration of anti-mouse CD25+ T-cell monoclonal antibody (PC61.5) 3 days after birth induced the development of GN with an increase in IgG2a antinuclear antibody, productions of IL-6 and IFN-γ, whereas TGF-β1 production decreased, compared to untreated control mice. The present study results suggest that CD4+CD25+ T cells may, at least in part, downregulate the development of GN during the preactive phase in B/WF1 mice.