Helicobacter pylori and Gastric Malignancies

  1. Masahiro Asaka1,
  2. Brigitte A. Dragosics2,*

Article first published online: 3 SEP 2004

DOI: 10.1111/j.1083-4389.2004.00252.x

Issue

Helicobacter

Helicobacter

Volume 9, Issue Supplement s1, pages 35–41, August 2004

Additional Information

How to Cite

Asaka, M. and Dragosics, B. A. (2004), Helicobacter pylori and Gastric Malignancies. Helicobacter, 9: 35–41. doi: 10.1111/j.1083-4389.2004.00252.x

Author Information

  1. 1

    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

  2. 2

    Department Vienna South, National Health Service, Vienna, Austria

* Brigitte A. Dragosics, Fasangartengasse 40/5, A-1130 Vienna, Austria. Tel.: + 43-1-804 95 38; + 43-676-602 85 95; E-mail: b.dragosics@gmx.at

Publication History

  1. Issue published online: 3 SEP 2004
  2. Article first published online: 3 SEP 2004

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Keywords:

  • Helicobacter pylori;
  • gastric cancer;
  • epidemiology;
  • pathogenesis;
  • cancer prevention

ABSTRACT

Clinical outcomes of Helicobacter pylori infection are diverse and caused by the variability of H. pylori virulence factors, host susceptibility, environmental factors and their interactions. Prospective epidemiological studies have clearly shown the relationship between H. pylori infection and gastric cancer. In addition, studies in animal models such as Mongolian gerbils with or without the addition of low-dose chemical carcinogens demonstrated that H. pylori infection can develop gastric carcinoma. Experimental studies have shown that virulence factors of H. pylori interact with gastric epithelial cell signaling related to carcinogenesis.

While the effect of H. pylori eradication on prevention of such tumors in chronic H. pylori carriers is still controversial, progress has been made in therapy especially of gastric lymphoma with well tolerated chemotherapeutic regimen.

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