Diagnosis of Helicobacter pylori Infection

  1. Athanasios Makristathis1,
  2. Alexander M. Hirschl1,
  3. Philippe Lehours2,
  4. Francis Mégraud2,*

Article first published online: 3 SEP 2004

DOI: 10.1111/j.1083-4389.2004.00254.x

Issue

Helicobacter

Helicobacter

Volume 9, Issue Supplement s1, pages 7–14, August 2004

Additional Information

How to Cite

Makristathis, A., Hirschl, A. M., Lehours, P. and Mégraud, F. (2004), Diagnosis of Helicobacter pylori Infection. Helicobacter, 9: 7–14. doi: 10.1111/j.1083-4389.2004.00254.x

Author Information

  1. 1

    Department of Clinical Microbiology, Institute of Hygiene and Medical Microbiology, Medical University Vienna, Vienna, Austria

  2. 2

    Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bordeaux, France

* Francis Mégraud, Laboratoire de Bactériologie, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux cedex, France. E-mail: francis.megraud@chu-bordeaux.fr

Publication History

  1. Issue published online: 3 SEP 2004
  2. Article first published online: 3 SEP 2004

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Keywords:

  • Culture;
  • molecular methods;
  • urea breath test;
  • stool antigen test;
  • serology

ABSTRACT

While there are some attempts to improve culture of Helicobacter pylori, molecular methods have been the main focus of this interest. Their main application concerns the development of rapid tests also allowing the determination of bacterial resistance, i.e. real-time polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH), or to genotype the strains. Attempts to improve, simplify or explain the discrepancies of urea breath test results have been made and new generation of stool antigen test with monoclonal antibodies either using the standard ELISA format or rapid immunoenzymatic detection have confirmed their value. With regard to serology, studies have mainly focused on the distinction of infections with more pathogenic strains and the ability to diagnose atrophic gastritis with the Gastropanel.

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