Curcumin and its derivatives prevent hepatocyte lipid peroxidation in Anabas testudineus

Authors

  • M. Manju,

    1. * Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India and Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India
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  • T. G. Sherin,

    1. * Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India and Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India
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  • K. N. Rajeesha,

    1. * Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India and Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India
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  • P. Sreejith,

    1. * Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India and Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India
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  • K. N. Rajasekharan,

    1. * Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India and Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India
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  • O. V. Oommen

    Corresponding author
    1. * Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India and Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India
      ‡Tel. and fax: +91 471 2418906; email: oommenvo@yahoo.com
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‡Tel. and fax: +91 471 2418906; email: oommenvo@yahoo.com

Abstract

The present study evaluated the effect of five different curcuminoids, CURI, CURII, CURIII, a mixture of the three and a synthetic, curcumin–boron–oxalic acid complex, on Anabas testudineus hepatocyte lipid peroxidation after 30–60 min of incubation. The results showed that curcumin had a protective role as a strong antioxidant in teleosts. All the curcuminoids decreased the peroxidation products formed, with or without stimulating the antioxidant enzyme pathway. This suggests a direct reactive oxygen-species scavenging ability of curcuminoids. Their antioxidant effects appear to be time and dose-dependent.

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