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Bactericidal activity of grass carp Ctenopharyngodon idella C9-deficient serum against Aeromonas hydrophila

Authors

  • C. Ji,

    1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China
    2. Graduate University of Chinese Academy of Sciences, Beijing, 100049, PR China
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  • A. H. Li,

    Corresponding author
    1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China
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  • J. Xie,

    1. Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, PR China
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  • D. F. Zhang,

    1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China
    2. Graduate University of Chinese Academy of Sciences, Beijing, 100049, PR China
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  • J. Y. Liu

    1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China
    2. Graduate University of Chinese Academy of Sciences, Beijing, 100049, PR China
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Tel.: +86 27 68780053; email: liaihua@ihb.ac.cn

Abstract

Neutralizing complement C9 in grass carp Ctenopharyngodon idella sera with rabbit anti-C9 sera against fish complement C9, demonstrated that bactericidal activity against Aeromonas hydrophila of the C9-deficient fish sera was greatly impaired. These results indicated that the fish complement C9 plays a key role in pathogen killing through the lytic pathway.

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