Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases
Article first published online: 28 APR 2009
© 2009 Japanese Dermatological Association
The Journal of Dermatology
Volume 36, Issue 6, pages 323–327, June 2009
How to Cite
INUI, S., NAKAJIMA, T., TODA, N. and ITAMI, S. (2009), Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases. The Journal of Dermatology, 36: 323–327. doi: 10.1111/j.1346-8138.2009.00647.x
- Issue published online: 28 MAY 2009
- Article first published online: 28 APR 2009
- Received 19 February 2009; accepted 26 June 2009.
- alopecia areata;
To study the effect of fexofenadine on extensive alopecia areata (AA), we evaluated retrospectively 121 patients with AA having alopecia in more than 50% of the scalp and followed them for at least 6 months. Patients were treated by immunotherapy using diphenylcyclopropenone or squaric acid dibutylester with or without oral fexofenadine. The regrowth score was estimated as decrease of Severity of Alopecia Tool (SALT) score. In AA with atopic background (atopic AA), the mean regrowth score of the fexofenadine group was 1.333 (n = 33) and that of the control 0.471 (n = 34). The fexofenadine group showed significantly better regrowth than control by Mann–Whitney's U-test (P = 0.00213). In non-atopic AA, the mean regrowth score of the fexofenadine group was 1.303 (n = 33) and that of the control 1.048 (n = 21). There was no significant difference by Mann–Whitney's U-test (P = 0.872). Together, fexofenadine is a helpful reagent in the treatment extensive atopic AA with contact immunotherapy.