Risk factors for psoriasis: A case–control study
Article first published online: 28 APR 2009
© 2009 Japanese Dermatological Association
The Journal of Dermatology
Volume 36, Issue 6, pages 328–334, June 2009
How to Cite
JANKOVIC, S., RAZNATOVIC, M., MARINKOVIC, J., JANKOVIC, J. and MAKSIMOVIC, N. (2009), Risk factors for psoriasis: A case–control study. The Journal of Dermatology, 36: 328–334. doi: 10.1111/j.1346-8138.2009.00648.x
- Issue published online: 28 MAY 2009
- Article first published online: 28 APR 2009
- Received 18 June 2008; accepted 19 February 2009.
- case–control study;
- family history;
- lifestyle factors;
A case–control study of 110 consecutive psoriatic outpatients and 200 unmatched controls was carried out in order to analyze the association of psoriasis with smoking habits, alcohol consumption, family history of psoriasis and stressful life events. Stressful life events were assessed with Paykel's Interview for Recent Life Events, a semi-structured interview covering 63 life events. According to our results, the risk of psoriasis is higher in urban dwellers (odds ratio [OR] = 3.61; 95% confidence interval [CI] = 0.99–13.18), patients who were divorced (OR = 5.69; 95% CI = 2.26–14.34) and those exposed to environmental tobacco smoke at home (OR = 2.29; 95% CI = 1.12–4.67). Alcohol consumption (OR = 2.55; 95% CI = 1.26–5.17), family history of psoriasis (OR = 33.96; 95% CI = 14.14–81.57) and change in work conditions (OR = 8.34; 95% CI = 1.86–37.43) are also risk factors for psoriasis. Separate analyses for men and women showed that the risk of developing psoriasis was stronger in men with a family history of psoriasis (OR = 30.39; 95% CI = 6.72–137.42) than in women (OR = 16.99; 95% CI = 7.21–40.07). The effect of environmental tobacco smoke at home was found only in women (OR = 2.44; 95% CI = 1.26–4.73). Future well-designed epidemiological studies need to be performed in order to determine whether lifestyle factors and stress could be risk factors triggering or aggravating psoriasis.