Extramammary Paget’s disease with intracytoplasmic lumen formation
Version of Record online: 26 NOV 2009
© 2009 Japanese Dermatological Association
The Journal of Dermatology
Volume 36, Issue 12, pages 649–653, December 2009
How to Cite
TSUNEMI, Y., SAEKI, H., KIKUCHI, K., TAMAKI, K. and SATO, S. (2009), Extramammary Paget’s disease with intracytoplasmic lumen formation. The Journal of Dermatology, 36: 649–653. doi: 10.1111/j.1346-8138.2009.00725.x
- Issue online: 26 NOV 2009
- Version of Record online: 26 NOV 2009
- Received 27 November 2008; accepted 16 September 2009.
- extramammary Paget’s disease;
- signet ring cell
Extramammary Paget’s disease (EMPD) is regarded as a malignancy most likely derived from or differentiated into apocrine sweat duct and gland. The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation. This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation. Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct.