All work in this study was performed in Turkey.
Association of human leukocyte antigen class II alleles with pemphigus vulgaris in a Turkish population
Article first published online: 26 FEB 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Special Issue: Blistering Diseases (pages 193-239)
Volume 37, Issue 3, pages 246–250, March 2010
How to Cite
TUNCA, M., MUSABAK, U., SAGKAN, R. I., KOC, E. and AKAR, A. (2010), Association of human leukocyte antigen class II alleles with pemphigus vulgaris in a Turkish population. The Journal of Dermatology, 37: 246–250. doi: 10.1111/j.1346-8138.2009.00743.x
- Issue published online: 26 FEB 2010
- Article first published online: 26 FEB 2010
- Received 20 June 2009; accepted 18 September 2009.
- class II allele;
- human leukocyte antigen;
- pemphigus vulgaris;
- Turkish patients
Pemphigus vulgaris (PV) is a severe autoimmune blistering skin disorder that is strongly associated with major histocompatibility complex class II alleles. Human leukocyte antigen (HLA) subtypes vary with racial/ethnic backgrounds. The purpose of this study was to determine the association of HLA class II alleles and haplotypes with PV in Turkish patients. Twenty-five patients with PV and 113 healthy transplant donors were genotyped for HLA class II alleles. HLA DNA typing was performed by the polymerase chain reaction/sequence specific primer method. The frequency of HLA DRB1*04 allele was 68.00% in patients compared to 30.97% in controls (P = 0.0012) and the frequency of HLA DRB1*14 allele was 32.00% in the patient group compared to 8.85% in the control group (P = 0.0054). Also, the frequency of HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes in PV patients was significantly higher than controls (32.0% vs 6.2%, χ2 = 28.142, P < 0.001; and 16% vs 2.7%, χ2 = 15.143, P = 0.001, respectively). A preventive allele or haplotype for the manifestation of PV has not been identified in this study. Our findings suggest that HLA DRB1*04 and DRB1*14 alleles, and HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes are genetic markers for general susceptibility to PV in the Turkish population.