Case of localized scleroderma successfully treated with bath psoralen and ultraviolet A therapy
Article first published online: 24 JAN 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Special Issue: Systemic Sclerosis (pages 1-84)
Volume 37, Issue 1, pages 75–80, January 2010
How to Cite
UCHIYAMA, M., OKUBO, Y., KAWASHIMA, H., YAMAMOTO, K., MITSUHASHI, Y. and TSUBOI, R. (2010), Case of localized scleroderma successfully treated with bath psoralen and ultraviolet A therapy. The Journal of Dermatology, 37: 75–80. doi: 10.1111/j.1346-8138.2009.00750.x
- Issue published online: 24 JAN 2010
- Article first published online: 24 JAN 2010
- Received 13 November 2008; accepted 16 September 2009.
- localized scleroderma;
- psoralen and ultraviolet A therapy
The patient was a 12-year-old girl with linear scleroderma distributed on the right abdomen, dorsal aspect of the right thigh, lower leg and foot. The initial regimen of oral prednisolone and methotrexate, or i.v. methylprednisolone failed in the treatment of the scleroderma. Then bath psoralen and ultraviolet A therapy (bath-PUVA) therapy of 0.2 J–4.0 J/cm2 daily to total doses 62.8 J/cm2 combined with oral prednisolone was started. After bath-PUVA therapy, regression of the skin sclerosis was observed, the possible mobile range of the right ankle was increased and histological examination confirmed improvement of the sclerosis. The successful results of bath-PUVA therapy in this case suggest its utility for localized scleroderma.